Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition

Epoxyeicosatrienoic acids (EETs) are metabolized by soluble epoxide hydrolase (sEH) to form dihydroxyeicosatrienoic acids (DHETs) and are putative endothelium-derived hyperpolarizing factors (EDHFs). EDHFs modulate microvascular tone; however, the chemical identity of EDHF in the human coronary micr...

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Detalhes bibliográficos
Main Authors: Larsen, Brandon T., Miura, Hiroto, Hatoum, Ossama A., Campbell, William B., Hammock, Bruce D., Zeldin, Darryl C., Falck, John R., Gutterman, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456013/
https://ncbi.nlm.nih.gov/pubmed/16258029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00927.2005
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