A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements

While decapping plays a major role in mRNA turnover in yeast, biochemical evidence for a similar activity in mammalian cells has been elusive. We have now identified a decapping activity in HeLa cytoplasmic extracts that releases (7me)GDP from capped transcripts. Decapping is activated in extracts b...

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Pubblicato in:	EMBO J
Autori principali:	Gao, Min, Wilusz, Carol J., Peltz, Stuart W., Wilusz, Jeffrey
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145468/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11230136/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.5.1134
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