A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements

While decapping plays a major role in mRNA turnover in yeast, biochemical evidence for a similar activity in mammalian cells has been elusive. We have now identified a decapping activity in HeLa cytoplasmic extracts that releases (7me)GDP from capped transcripts. Decapping is activated in extracts b...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Gao, Min, Wilusz, Carol J., Peltz, Stuart W., Wilusz, Jeffrey
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145468/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11230136/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.5.1134
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