Mechanism of the spatio-temporal regulation of Ras and Rap1

Epidermal growth factor (EGF) activates Ras and Rap1 at distinct intracellular regions. Here, we explored the mechanism underlying this phenomenon. We originally noticed that in cells expressing Epac, a cAMP-dependent Rap1 GEF (guanine nucleotide exchange factor), cAMP activated Rap1 at the perinucl...

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Publié dans:	EMBO J
Auteurs principaux:	Ohba, Yusuke, Kurokawa, Kazuo, Matsuda, Michiyuki
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 2003
Sujets:	Articles
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145447/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12574122/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg087
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