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Mechanism of the spatio-temporal regulation of Ras and Rap1
Epidermal growth factor (EGF) activates Ras and Rap1 at distinct intracellular regions. Here, we explored the mechanism underlying this phenomenon. We originally noticed that in cells expressing Epac, a cAMP-dependent Rap1 GEF (guanine nucleotide exchange factor), cAMP activated Rap1 at the perinucl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC145447/ https://ncbi.nlm.nih.gov/pubmed/12574122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg087 |
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