Using Drosophila to Decipher How Mutations Associated With Human Branchio-Oto-Renal Syndrome and Optical Defects Compromise the Protein Tyrosine Phosphatase and Transcriptional Functions of Eyes Absent

Eyes absent (EYA) proteins are defined by a conserved C-terminal EYA domain (ED) that both contributes to its function as a transcriptional coactivator by mediating protein-protein interactions and possesses intrinsic protein tyrosine phosphatase activity. Mutations in human EYA1 result in an autoso...

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Bibliographic Details
Main Authors: Mutsuddi, Mousumi, Chaffee, Benjamin, Cassidy, Justin, Silver, Serena J., Tootle, Tina L., Rebay, Ilaria
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2005
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450419/
https://ncbi.nlm.nih.gov/pubmed/15802522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.039156
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