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Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a)
Increased mitogenic signaling by positive effectors such as Ras or Myc can trigger senescence in normal cells, a response believed to function as a tumor-suppressive mechanism. We report here the existence of a checkpoint that monitors hypoproliferative signaling imbalances. Normal human fibroblasts...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1450136/ https://ncbi.nlm.nih.gov/pubmed/16537449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600069103 |
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