Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47(phox) in recognition of a polyproline type II helix and an adjacent α-helix of p22(phox)

Activation of the superoxide-producing phagocyte NADPH oxidase, crucial for host defence, requires an SH3 (Src homology 3)-domain-mediated interaction of the regulatory protein p47(phox) with p22(phox), a subunit of the oxidase catalytic core flavocytochrome b(558). Although previous analysis of a c...

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Autori principali: Nobuhisa, Ikuo, Takeya, Ryu, Ogura, Kenji, Ueno, Noriko, Kohda, Daisuke, Inagaki, Fuyuhiko, Sumimoto, Hideki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449995/
https://ncbi.nlm.nih.gov/pubmed/16460309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051899
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