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α-Synuclein Targets the Plasma Membrane via the Secretory Pathway and Induces Toxicity in Yeast
A pathological feature of Parkinson's disease is the presence of Lewy bodies within selectively vulnerable neurons. These are ubiquitinated cytoplasmic inclusions containing α-synuclein, an abundant protein normally associated with presynaptic terminals. Point mutations in the α-synuclein gene...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Genetics Society of America
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1449710/ https://ncbi.nlm.nih.gov/pubmed/15744056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.035493 |
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