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Evidence for the ancient origin of the NF-κB/IκB cascade: Its archaic role in pathogen infection and immunity
The evolutionary conservation of the NF-κB transcription factors, from Drosophila to humans, underscores its pivotal role in immune response. Unexpectedly, the canonical NF-κB signaling pathway is not functional in the immune system of Caenorhabditis elegans. Therefore, the ancient origin of the NF-...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1449671/ https://ncbi.nlm.nih.gov/pubmed/16537509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507044103 |
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