Identification of the minimal protein-folding nucleus through loop-entropy perturbations

To explore the plasticity and structural constraints of the protein-folding nucleus we have constructed through circular permutation four topological variants of the ribosomal protein S6. In effect, these topological variants represent entropy mutants with maintained spatial contacts. The proteins w...

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Bibliographic Details
Main Authors: Lindberg, Magnus O., Haglund, Ellinor, Hubner, Isaac A., Shakhnovich, Eugene I., Oliveberg, Mikael
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449650/
https://ncbi.nlm.nih.gov/pubmed/16505376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508863103
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