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Testing for Hardy-Weinberg Equilibrium in Samples With Related Individuals

When the classical χ(2) goodness-of-fit test for Hardy-Weinberg (HW) equilibrium is used on samples with related individuals, the type I error can be greatly inflated. In particular the test is inappropriate in population isolates where the individuals are related through multiple lines of descent....

詳細記述

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書誌詳細
主要な著者: Bourgain, Catherine, Abney, Mark, Schneider, Daniel, Ober, Carole, McPeek, Mary Sara
フォーマット: Artigo
言語:Inglês
出版事項: Genetics Society of America 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1448754/
https://ncbi.nlm.nih.gov/pubmed/15371359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.031617
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