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Testing for Hardy-Weinberg Equilibrium in Samples With Related Individuals

When the classical χ(2) goodness-of-fit test for Hardy-Weinberg (HW) equilibrium is used on samples with related individuals, the type I error can be greatly inflated. In particular the test is inappropriate in population isolates where the individuals are related through multiple lines of descent....

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Bibliografski detalji
Glavni autori: Bourgain, Catherine, Abney, Mark, Schneider, Daniel, Ober, Carole, McPeek, Mary Sara
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1448754/
https://ncbi.nlm.nih.gov/pubmed/15371359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.031617
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