A TNF receptor loop peptide mimic blocks RANK ligand–induced signaling, bone resorption, and bone loss

Activating receptor activator of NF-κB (RANK) and TNF receptor (TNFR) promote osteoclast differentiation. A critical ligand contact site on the TNFR is partly conserved in RANK. Surface plasmon resonance studies showed that a peptide (WP9QY) that mimics this TNFR contact site and inhibits TNF-α–indu...

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Bibliografiske detaljer
Main Authors: Aoki, Kazuhiro, Saito, Hiroaki, Itzstein, Cecile, Ishiguro, Masaji, Shibata, Tatsuya, Blanque, Roland, Mian, Anower Hussain, Takahashi, Mariko, Suzuki, Yoshifumi, Yoshimatsu, Masako, Yamaguchi, Akira, Deprez, Pierre, Mollat, Patrick, Murali, Ramachandran, Ohya, Keiichi, Horne, William C., Baron, Roland
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1448165/
https://ncbi.nlm.nih.gov/pubmed/16680194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI22513
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