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Leaky Scanning and Reinitiation Regulate BACE1 Gene Expression

β-Site β-amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is the β-secretase in vivo for processing APP to generate amyloid β protein (Aβ). Aβ deposition in the brain is the hallmark of Alzheimer's disease (AD) neuropathology. Inhibition of BACE1 activity has major pharmaceutical poten...

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Bibliografske podrobnosti
Main Authors: Zhou, Weihui, Song, Weihong
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1447409/
https://ncbi.nlm.nih.gov/pubmed/16611980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.9.3353-3364.2006
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