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Leaky Scanning and Reinitiation Regulate BACE1 Gene Expression
β-Site β-amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is the β-secretase in vivo for processing APP to generate amyloid β protein (Aβ). Aβ deposition in the brain is the hallmark of Alzheimer's disease (AD) neuropathology. Inhibition of BACE1 activity has major pharmaceutical poten...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2006
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1447409/ https://ncbi.nlm.nih.gov/pubmed/16611980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.9.3353-3364.2006 |
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