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Rac1-null Mouse Embryonic Fibroblasts Are Motile and Respond to Platelet-derived Growth Factor

Previous studies of Rac1 in fibroblasts have used dominant negative constructs, which may have nonspecific effects. We used a conditional Rac1 allele to critically examine Rac1 function in mouse fibroblasts. Lack of Rac1 had dramatic effects on nonconfluent cells, which were elongated and had extens...

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מידע ביבליוגרפי
Main Authors: Vidali, Luis, Chen, Feng, Cicchetti, Gregor, Ohta, Yasutaka, Kwiatkowski, David J.
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Cell Biology 2006
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1446085/
https://ncbi.nlm.nih.gov/pubmed/16525021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-10-0955
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