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Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain
Snu114 is a U5 snRNP protein essential for pre-mRNA splicing. Based on its homology with the ribosomal translocase EF-G, it is thought that GTP hydrolysis by Snu114 induces conformational rearrangements in the spliceosome. We recently identified allele-specific genetic interactions between SNU114 an...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cold Spring Harbor Laboratory Press
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1440915/ https://ncbi.nlm.nih.gov/pubmed/16540695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2319806 |
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