Use of transcriptional synergy to augment sensitivity of a splicing reporter assay

A primary limitation in the development and use of screens to identify factors that regulate mammalian pre-mRNA splicing has been the development of sensitive reporter assays. Alternative splicing typically involves relatively small (< 10-fold) changes in isoform ratios. Therefore, reporter const...

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Dettagli Bibliografici
Autori principali: Levinson, Noah, Hinman, Rochelle, Patil, Ashwini, Stephenson, Corey R.J., Werner, Stefan, Woo, Grace H.C., Xiao, Jingbo, Wipf, Peter, Lynch, Kristen W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2006
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440914/
https://ncbi.nlm.nih.gov/pubmed/16556940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.8306
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