Profiles of Global Gene Expression in Ionizing-Radiation–Damaged Human Diploid Fibroblasts Reveal Synchronization behind the G(1) Checkpoint in a G(0)-like State of Quiescence

Cell cycle arrest and stereotypic transcriptional responses to DNA damage induced by ionizing radiation (IR) were quantified in telomerase-expressing human diploid fibroblasts. Analysis of cytotoxicity demonstrated that 1.5 Gy IR inactivated colony formation by 40–45% in three fibroblast lines; this...

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Detalhes bibliográficos
Main Authors: Zhou, Tong, Chou, Jeff W., Simpson, Dennis A., Zhou, Yingchun, Mullen, Thomas E., Medeiros, Margarida, Bushel, Pierre R., Paules, Richard S., Yang, Xuebin, Hurban, Patrick, Lobenhofer, Edward K., Kaufmann, William K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Institute of Environmental Health Sciences 2006
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440780/
https://ncbi.nlm.nih.gov/pubmed/16581545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.8026
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