Origins of Proton Transport Behavior from Selectivity Domain Mutations of the Aquaporin-1 Channel

The permeation free-energy profile and maximum ion conductance of proton transport along the channel of three aquaporin-1 (AQP1) mutants (H180A/R195V, H180A, and R195V) are calculated via molecular dynamics simulations and Poisson-Nernst-Planck theory. The proton dynamics was described by the multis...

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Bibliographic Details
Main Authors: Chen, Hanning, Wu, Yujie, Voth, Gregory A.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2006
Subjects:
Biophysical Letters
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440765/
https://ncbi.nlm.nih.gov/pubmed/16581846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.084061
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