Mucosal Immunization with Surface-Displayed Severe Acute Respiratory Syndrome Coronavirus Spike Protein on Lactobacillus casei Induces Neutralizing Antibodies in Mice

Induction of mucosal immunity may be important for preventing SARS-CoV infections. For safe and effective delivery of viral antigens to the mucosal immune system, we have developed a novel surface antigen display system for lactic acid bacteria using the poly-γ-glutamic acid synthetase A protein (Pg...

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Detalhes bibliográficos
Main Authors: Lee, Jong-Soo, Poo, Haryoung, Han, Dong P., Hong, Seung-Pyo, Kim, Kwang, Cho, Michael W., Kim, Eun, Sung, Moon-Hee, Kim, Chul-Joong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440448/
https://ncbi.nlm.nih.gov/pubmed/16571824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.8.4079-4087.2006
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