Mucosal Vaccination with Recombinant Lactobacillus casei-Displayed CTA1-Conjugated Consensus Matrix Protein-2 (sM2) Induces Broad Protection against Divergent Influenza Subtypes in BALB/c Mice

To develop a safe and effective mucosal vaccine against pathogenic influenza viruses, we constructed recombinant Lactobacillus casei strains that express conserved matrix protein 2 with (pgsA-CTA1-sM2/L. casei) or without (pgsA-sM2/L. casei) cholera toxin subunit A1 (CTA1) on the surface. The surfac...

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Detalhes bibliográficos
Main Authors: Chowdhury, Mohammed Y. E., Li, Rui, Kim, Jae-Hoon, Park, Min-Eun, Kim, Tae-Hwan, Pathinayake, Prabuddha, Weeratunga, Prasanna, Song, Man Ki, Son, Hwa-Young, Hong, Seung-Pyo, Sung, Moon-Hee, Lee, Jong-Soo, Kim, Chul-Joong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979752/
https://ncbi.nlm.nih.gov/pubmed/24714362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094051
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