Envelope Conformational Changes Induced by Human Immunodeficiency Virus Type 1 Attachment Inhibitors Prevent CD4 Binding and Downstream Entry Events

BMS-488043 is a small-molecule human immunodeficiency virus type 1 (HIV-1) CD4 attachment inhibitor with demonstrated clinical efficacy. The compound inhibits soluble CD4 (sCD4) binding to the 11 distinct HIV envelope gp120 proteins surveyed. Binding of BMS-488043 and that of sCD4 to gp120 are mutua...

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Detalhes bibliográficos
Main Authors: Ho, Hsu-Tso, Fan, Li, Nowicka-Sans, Beata, McAuliffe, Brian, Li, Chang-Ben, Yamanaka, Gregory, Zhou, Nannan, Fang, Hua, Dicker, Ira, Dalterio, Richard, Gong, Yi-Fei, Wang, Tao, Yin, Zhiwei, Ueda, Yasutsugu, Matiskella, John, Kadow, John, Clapham, Paul, Robinson, James, Colonno, Richard, Lin, Pin-Fang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440438/
https://ncbi.nlm.nih.gov/pubmed/16571818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.8.4017-4025.2006
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