Intrarectal Immunization with Rotavirus 2/6 Virus-Like Particles Induces an Antirotavirus Immune Response Localized in the Intestinal Mucosa and Protects against Rotavirus Infection in Mice

Rotavirus (RV) is the main etiological agent of severe gastroenteritis in infants, and vaccination seems the most effective way to control the disease. Recombinant rotavirus-like particles composed of the viral protein 6 (VP6) and VP2 (2/6-VLPs) have been reported to induce protective immunity in mi...

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Detalhes bibliográficos
Main Authors: Agnello, Davide, Hervé, Christine A., Lavaux, Amandine, Darniot, Magali, Guillon, Patrice, Charpilienne, Annie, Pothier, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440434/
https://ncbi.nlm.nih.gov/pubmed/16571799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.8.3823-3832.2006
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