Membrane-Anchored Inhibitory Peptides Capture Human Immunodeficiency Virus Type 1 gp41 Conformations That Engage the Target Membrane prior to Fusion

Soluble peptides derived from the C-terminal heptad repeat domain of human immunodeficiency virus type 1 (HIV-1) gp41 are potent inhibitors of HIV-1 entry and gp41-induced fusion. Target membrane-anchored variants of these peptides have been shown to retain inhibitory activity. Both soluble and memb...

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Hauptverfasser: Melikyan, Gregory B., Egelhofer, Marc, von Laer, Dorothee
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440409/
https://ncbi.nlm.nih.gov/pubmed/16537592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.7.3249-3258.2006
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