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Nucleotide exchange via local protein unfolding—structure of Rab8 in complex with MSS4

Rab GTPases function as essential regulators of vesicle transport in eukaryotic cells. MSS4 was shown to stimulate nucleotide exchange on Rab proteins associated with the exocytic pathway and to have nucleotide-free-Rab chaperone activity. A detailed kinetic analysis of MSS4 interaction with Rab8 sh...

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Detalhes bibliográficos
Main Authors: Itzen, Aymelt, Pylypenko, Olena, Goody, Roger S, Alexandrov, Kirill, Rak, Alexey
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440319/
https://ncbi.nlm.nih.gov/pubmed/16541104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601044
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