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Enhanced Production of Recombinant Proteins in Escherichia coli by Filamentation Suppression
During growth of high-cell-density cultures of Escherichia coli, overproduction of recombinant proteins often results in increased stress response, cell filamentation, and growth cessation. Filamentation of cells consequently lowers final achievable cell concentration and productivity of the target...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2003
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC143674/ https://ncbi.nlm.nih.gov/pubmed/12571061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.69.2.1295-1298.2003 |
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