4-1BB (CD137) Differentially Regulates Murine In Vivo Protein- and Polysaccharide-Specific Immunoglobulin Isotype Responses to Streptococcus pneumoniae

4-1BB (CD137) is induced on activated CD4(+) and CD8(+) T cells and delivers a costimulatory signal upon binding the 4-1BB ligand (4-1BBL) expressed on antigen-presenting cells. Induction of 4-1BB is dependent on activation via the T-cell receptor (TCR) and possibly CD28. It was previously demonstra...

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Autores principales: Wu, Zheng-Qi, Khan, Abdul Q., Shen, Yi, Wolcott, Karen M., Dawicki, Wojciech, Watts, Tania H., Mittler, Robert S., Snapper, Clifford M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Microbial Immunity and Vaccines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC143421/
https://ncbi.nlm.nih.gov/pubmed/12496166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.1.196-204.2003
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