Somatic Hypermutation and Diverse Immunoglobulin Gene Usage in the Human Antibody Response to the Capsular Polysaccharide of Streptococcus pneumoniae Type 6B

Combinatorial cloning and expression library analysis were used to determine the expressed human antibody repertoire specific for the capsular polysaccharide (PS) of Streptococcus pneumoniae serotype 6B. Sequence analysis of 55 6B-specific antibody Fab fragments isolated from six vaccinated donors r...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Zhou, Jianhui, Lottenbach, Kathleen R., Barenkamp, Stephen J., Reason, Donald C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2004
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC415722/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15155658/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.72.6.3505-3514.2004
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