Somatic Hypermutation and Diverse Immunoglobulin Gene Usage in the Human Antibody Response to the Capsular Polysaccharide of Streptococcus pneumoniae Type 6B

Combinatorial cloning and expression library analysis were used to determine the expressed human antibody repertoire specific for the capsular polysaccharide (PS) of Streptococcus pneumoniae serotype 6B. Sequence analysis of 55 6B-specific antibody Fab fragments isolated from six vaccinated donors r...

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Detalles Bibliográficos
Main Authors: Zhou, Jianhui, Lottenbach, Kathleen R., Barenkamp, Stephen J., Reason, Donald C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Microbial Immunity and Vaccines
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC415722/
https://ncbi.nlm.nih.gov/pubmed/15155658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.6.3505-3514.2004
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