Changes in the gastric mucosa of the mouse associated with long lasting unsurmountable histamine H2 blockade.

The oral administration of loxtidine to mice at doses of 600, 250, and 50 mg/kg/day for 746 days produced carcinoid tumours of the gastric fundus. The fundic mucosa also showed marked atypical hyperplasia with changes in foveolar cells similar to those seen in early incomplete metaplasia. These effe...

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Bibliographic Details
Main Authors: Poynter, D, Selway, S A, Papworth, S A, Riches, S R
Format: Artigo
Language:Inglês
Published: 1986
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1434077/
https://ncbi.nlm.nih.gov/pubmed/2878860
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