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Effect of Histamine and Its Methyl Derivatives on Cyclic AMP Metabolism in Gastric Mucosa and Its Blockade by an H(2) Receptor Antagonist

In a cell-free system prepared from guinea pig gastric mucosa, histamine and Nα-methyl-histamine produced dose-dependent stimulation of cyclic AMP formation and 1,4-methylhistamine had a minimal stimulatory effect. N-methyl-N′-(2-[5-methylimidazole-4-yl-methylthio]-ethyl) -thiourea (metiamide), a ne...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Dousa, Thomas P., Code, Charles F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1974
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301469/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4148625/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI107555
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