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Effect of Histamine and Its Methyl Derivatives on Cyclic AMP Metabolism in Gastric Mucosa and Its Blockade by an H(2) Receptor Antagonist
In a cell-free system prepared from guinea pig gastric mucosa, histamine and Nα-methyl-histamine produced dose-dependent stimulation of cyclic AMP formation and 1,4-methylhistamine had a minimal stimulatory effect. N-methyl-N′-(2-[5-methylimidazole-4-yl-methylthio]-ethyl) -thiourea (metiamide), a ne...
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| Published in: | J Clin Invest |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Clinical Investigation
1974
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301469/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4148625/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI107555 |
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