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Association of long lasting unsurmountable histamine H2 blockade and gastric carcinoid tumours in the rat.

The oral administration of loxtidine, a potent histamine H2-antagonist, to a total of 378 rats at doses of 50, 185, or 685 mg/kg/day for 116 weeks resulted in the late formation of carcinoid tumours of the gastric fundus. The first such tumour was detected after 712 days of treatment. There was no d...

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Detalhes bibliográficos
Main Authors: Poynter, D, Pick, C R, Harcourt, R A, Selway, S A, Ainge, G, Harman, I W, Spurling, N W, Fluck, P A, Cook, J L
Formato: Artigo
Idioma:Inglês
Publicado em: 1985
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1433126/
https://ncbi.nlm.nih.gov/pubmed/2867954
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