MprF-Mediated Lysinylation of Phospholipids in Staphylococcus aureus Leads to Protection against Oxygen-Independent Neutrophil Killing

Staphylococcus aureus achieves resistance to defensins and similar cationic antimicrobial peptides (CAMPs) by modifying anionic membrane lipids via MprF with l-lysine, which leads to repulsion of these host defense molecules. S. aureus ΔmprF, which lacks the modification, was very efficiently killed...

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Bibliographic Details

Published in:	Infect Immun
Main Authors:	Kristian, Sascha A., Dürr, Manuela, Van Strijp, Jos A. G., Neumeister, Birgid, Peschel, Andreas
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2003
Subjects:	Host Response and Inflammation
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC143157/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12496209/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.1.546-549.2003
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