MprF-Mediated Lysinylation of Phospholipids in Staphylococcus aureus Leads to Protection against Oxygen-Independent Neutrophil Killing

Staphylococcus aureus achieves resistance to defensins and similar cationic antimicrobial peptides (CAMPs) by modifying anionic membrane lipids via MprF with l-lysine, which leads to repulsion of these host defense molecules. S. aureus ΔmprF, which lacks the modification, was very efficiently killed...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kristian, Sascha A., Dürr, Manuela, Van Strijp, Jos A. G., Neumeister, Birgid, Peschel, Andreas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2003
Gaiak:
Host Response and Inflammation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC143157/
https://ncbi.nlm.nih.gov/pubmed/12496209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.1.546-549.2003
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