Tankyrase 2 Poly(ADP-Ribose) Polymerase Domain-Deleted Mice Exhibit Growth Defects but Have Normal Telomere Length and Capping

Regulation of telomere length maintenance and capping are a critical cell functions in both normal and tumor cells. Tankyrase 2 (Tnks2) is a poly(ADP-ribose) polymerase (PARP) that has been shown to modify itself and TRF1, a telomere-binding protein. We show here by overexpression studies that tanky...

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Autors principals: Hsiao, Susan J., Poitras, Marc F., Cook, Brandoch D., Liu, Yie, Smith, Susan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430302/
https://ncbi.nlm.nih.gov/pubmed/16507985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.6.2044-2054.2006
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