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Active Role for Nibrin in the Kinetics of Atm Activation
The Atm protein kinase is central to the DNA double-strand break response in mammalian cells. After irradiation, dimeric Atm undergoes autophosphorylation at Ser 1981 and dissociates into active monomers. Atm activation is stimulated by expression of the Mre11/Rad50/nibrin complex. Previously, we sh...
Tallennettuna:
| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Microbiology
2006
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1430256/ https://ncbi.nlm.nih.gov/pubmed/16478990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.5.1691-1699.2006 |
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