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Active Role for Nibrin in the Kinetics of Atm Activation

The Atm protein kinase is central to the DNA double-strand break response in mammalian cells. After irradiation, dimeric Atm undergoes autophosphorylation at Ser 1981 and dissociates into active monomers. Atm activation is stimulated by expression of the Mre11/Rad50/nibrin complex. Previously, we sh...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cerosaletti, Karen, Wright, Jocyndra, Concannon, Patrick
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430256/
https://ncbi.nlm.nih.gov/pubmed/16478990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.5.1691-1699.2006
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