In Vitro Development of Resistance to Human Immunodeficiency Virus Protease Inhibitor GW640385

Development of in vitro resistance to GW640385, a new human immunodeficiency virus type 1 protease inhibitor, was studied. Variants characterized included one with <4-fold resistance and amino acid substitutions Q58E/A71V (protease) and P452K (Gag) and one with >50-fold resistance and amino ac...

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Main Authors: Yates, P. J., Hazen, R., St. Clair, M., Boone, L., Tisdale, M., Elston, R. C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1426426/
https://ncbi.nlm.nih.gov/pubmed/16495277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.3.1092-1095.2006
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