Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity

According to the protein-only hypothesis of prion propagation, prions are composed principally of PrP(Sc), an abnormal conformational isoform of the prion protein, which, like its normal cellular precursor (PrP(C)), has a GPI (glycosylphosphatidylinositol) anchor at the C-terminus. To date, elucidat...

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Bibliographic Details
Main Authors: Lewis, Patrick A., Properzi, Francesca, Prodromidou, Kanella, Clarke, Anthony R., Collinge, John, Jackson, Graham S.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2006
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1422754/
https://ncbi.nlm.nih.gov/pubmed/16441239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051677
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