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HUMAN CATIONIC TRYPSINOGEN. THE TETRA-ASPARTATE MOTIF IN THE ACTIVATION PEPTIDE IS ESSENTIAL FOR AUTOACTIVATION CONTROL, BUT NOT FOR ENTEROPEPTIDASE RECOGNITION.
The activation peptide of vertebrate trypsinogens contains a highly conserved tetra-aspartate sequence (Asp(19–22) in humans) preceding the Lys-Ile scissile bond. A large body of research has defined the primary role of this acidic motif as a specific recognition site for enteropeptidase, the physio...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1420407/ https://ncbi.nlm.nih.gov/pubmed/15970597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M505661200 |
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