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HUMAN CATIONIC TRYPSINOGEN. THE TETRA-ASPARTATE MOTIF IN THE ACTIVATION PEPTIDE IS ESSENTIAL FOR AUTOACTIVATION CONTROL, BUT NOT FOR ENTEROPEPTIDASE RECOGNITION.

The activation peptide of vertebrate trypsinogens contains a highly conserved tetra-aspartate sequence (Asp(19–22) in humans) preceding the Lys-Ile scissile bond. A large body of research has defined the primary role of this acidic motif as a specific recognition site for enteropeptidase, the physio...

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Detalhes bibliográficos
Main Authors: Nemoda, Zsófia, Sahin-Tóth, Miklós
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1420407/
https://ncbi.nlm.nih.gov/pubmed/15970597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M505661200
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