Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells

The androgen receptor not only mediates prostate development but also serves as a key regulator of primary prostatic cancer growth. Although initially responsive to selective androgen receptor modulators (SARMs), which cause recruitment of the nuclear receptor–corepressor (N-CoR) complex, resistance...

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Autori principali: Baek, Sung Hee, Ohgi, Kenneth A., Nelson, Charles A., Welsbie, Derek, Chen, Charlie, Sawyers, Charles L., Rose, David W., Rosenfeld, Michael G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413901/
https://ncbi.nlm.nih.gov/pubmed/16492776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510842103
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