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The Vif and Vpr accessory proteins independently cause HIV-1-induced T cell cytopathicity and cell cycle arrest

HIV type I (HIV-1) can cause G(2) cell cycle arrest and death of CD4(+) T lymphocytes in vitro and inexorable depletion of these cells in vivo. However, the molecular mechanism of viral cytopathicity has not been satisfactorily elucidated. Previously, we showed that HIV-1 kills T cells by a necrotic...

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Bibliografski detalji
Glavni autori: Sakai, Keiko, Dimas, Joseph, Lenardo, Michael J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413893/
https://ncbi.nlm.nih.gov/pubmed/16492778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509417103
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