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HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation

The activation of IRF-3 during the early stages of viral infection is critical for the initiation of the antiviral response; however the activation of IRF-3 in HIV-1 infected cells has not yet been characterized. We demonstrate that the early steps of HIV-1 infection do not lead to the activation an...

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Detalhes bibliográficos
Main Authors: Okumura, Atushi, Alce, Tim, Lubyova, Barbora, Ezelle, Heather, Strebel, Klaus, Pitha, Paula M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2312338/
https://ncbi.nlm.nih.gov/pubmed/18082865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.10.042
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