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Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling
Protein tyrosine phosphatase 1B (PTP-1B) is a ubiquitously expressed cytosolic phosphatase with the ability to dephosphorylate JAK2 and TYK2, and thereby down-regulate cytokine receptor signaling. Furthermore, PTP-1B levels are up-regulated in certain chronic myelogenous leukemia patients, which poi...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413784/ https://ncbi.nlm.nih.gov/pubmed/16477024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508563103 |
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