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Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling

Protein tyrosine phosphatase 1B (PTP-1B) is a ubiquitously expressed cytosolic phosphatase with the ability to dephosphorylate JAK2 and TYK2, and thereby down-regulate cytokine receptor signaling. Furthermore, PTP-1B levels are up-regulated in certain chronic myelogenous leukemia patients, which poi...

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Библиографические подробности
Главные авторы: Heinonen, Krista M., Dubé, Nadia, Bourdeau, Annie, Lapp, Wayne S., Tremblay, Michel L.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413784/
https://ncbi.nlm.nih.gov/pubmed/16477024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508563103
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