Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation

Sarcolipin (SLN) inhibits the cardiac sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a) by direct binding and is superinhibitory if it binds as a binary complex with phospholamban (PLN). To demonstrate whether overexpression of SLN in the heart might impair cardiac function directly, transgenic (...

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Hlavní autoři: Gramolini, Anthony O., Trivieri, Maria G., Oudit, Gavin Y., Kislinger, Thomas, Li, Wenping, Patel, Mikin M., Emili, Andrew, Kranias, Evangelia G., Backx, Peter H., MacLennan, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413737/
https://ncbi.nlm.nih.gov/pubmed/16461894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510883103
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