Loss of HR6B Ubiquitin-Conjugating Activity Results in Damaged Synaptonemal Complex Structure and Increased Crossing-Over Frequency during the Male Meiotic Prophase

The ubiquitin-conjugating enzymes HR6A and HR6B are the two mammalian homologs of Saccharomyces cerevisiae RAD6. In yeast, RAD6 plays an important role in postreplication DNA repair and in sporulation. HR6B knockout mice are viable, but spermatogenesis is markedly affected during postmeiotic steps,...

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Detalhes bibliográficos
Main Authors: Baarends, Willy M., Wassenaar, Evelyne, Hoogerbrugge, Jos W., van Cappellen, Gert, Roest, Henk P., Vreeburg, Jan, Ooms, Marja, Hoeijmakers, Jan H. J., Grootegoed, J. Anton
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC141135/
https://ncbi.nlm.nih.gov/pubmed/12556476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.4.1151-1162.2003
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