The Ubiquitin-Conjugating DNA Repair Enzyme HR6A Is a Maternal Factor Essential for Early Embryonic Development in Mice

The Saccharomyces cerevisiae RAD6 protein is required for a surprising diversity of cellular processes, including sporulation and replicational damage bypass of DNA lesions. In mammals, two RAD6-related genes, HR6A and HR6B, encode highly homologous proteins. Here, we describe the phenotype of cells...

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Detalhes bibliográficos
Main Authors: Roest, Henk P., Baarends, Willy M., de Wit, Jan, van Klaveren, Jan W., Wassenaar, Evelyne, Hoogerbrugge, Jos W., van Cappellen, Wiggert A., Hoeijmakers, Jan H. J., Grootegoed, J. Anton
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC419895/
https://ncbi.nlm.nih.gov/pubmed/15169909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.12.5485-5495.2004
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